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Generic for zoloft 50 mg /day) two weeks or eight week treatment with an equivalent dose of the active drug (zoloft 50 mg/day) as compared to placebo (placebo). There is also a trend, but it is not statistically significant in favor of zoloft, but when using data from those who completed the study, difference was not significant (see ). Table 2. Study Open in a separate window (a) Zoloft (N=917) Placebo (N=917)= 0.5 mg/week Zoloft 1 5 10 (b) (N=1026) Placebo (N=1026)= Zoloft 0.1 mg/week 1 5 10 Zoloft (c) (N=1331) Placebo (N=1331)= 50 mg/week Zoloft 100 Figure 3. View largeDownload slide Kaplan-Meier Zoloft 60 Pills 100mg $69 - $1.15 Per pill survival curves of patients treated with (a) zoloft 50 mg/day (orange line) and (b) zoloft 0.05 mg/day (blue line) for 2 years. The zoloft 50 mg/day treatment significantly reduced all-cause and cardiovascular death rates but not for nonfatal myocardial infarction. Discussion Our study has shown that zoloft (zoloft) tablets and the equivalent active drug (zoloft 50 mg/day) offer better safety and efficacy than placebo for the secondary prevention of coronary heart disease (CHD). There is also some evidence that zoloft leads to a longer lasting Atovaquone proguanil generic malarone reduction in the number of myocardial infarctions and/or death than placebo. These results could be explained with some evidence from a large prospective study (Zoloft in Secondary Prevention: The Zoloft Randomized Trial) in which the number of myocardial infarctions and deaths among patients taking zoloft was substantially lower than among those who took no treatment. The trial also showed that zoloft reduced all-cause mortality, stroke, acute CHD, and cardiovascular, respiratory, renal events had no adverse effects, and it showed a significant benefit by the end of 2 years. These effects have been associated with zoloft at the doses used in this trial and have been confirmed in later studies including more advanced treatment with zoloft. In a larger randomized trial using zoloft 50 mg/day for 10 years, the number of MI, fatal and non-fatal revascularization procedures remained significantly lower than for the placebo group. In addition to the increased safety and effectiveness of zoloft, its use in secondary prevention is likely to induce fewer adverse effects. Zoloft seems to be recommended for secondary prevention based on previous clinical trials and randomized that used the appropriate doses for clinical conditions and were well tolerated. Zoloft was initially marketed as a sedative in the 1950s, with aim of treating sleep disorders and anxiety. The use of benzodiazepines became widespread in the 1960s as a part of the mainstream treatment depression and anxiety, but due to their association with abuse they were removed from the market in 1973 US. Zoloft is one of a group benzodiazepines called the benzodiazepine-tropic compounds, and it was the first marketed benzodiazepine to be approved for use in the secondary prevention of CHD. The zoloft 50 mg/day dose was chosen because in clinical practice doses of 200–300 mg/day are commonly used and can be associated with greater safety, more favorable cardiovascular and neuropsychological effects, improved efficacy. Although 50 mg/day is slightly higher than for many other benzodiazepines, doses of 300–400 mg/day, especially the higher doses, do present considerable complications associated with side effects such as.
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